The effects of moderate alterations in adrenergic activity on acute appetite regulation in obese women: A randomised crossover trial.
Nutr Health
; 26(4): 311-322, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-32729763
ABSTRACT
BACKGROUND:
Previous evidence has demonstrated that serum leptin is correlated with appetite in combination with, but not without, modest exercise.AIM:
The present experiments investigated the effects of exogenous adrenaline and α/ß adrenoceptor blockade in combination with moderate exercise on serum leptin concentrations, appetite/satiety sensations and subsequent food intake in obese women.METHODS:
A total of 10 obese women ((mean ± SEM), age 50 (1.9) years, body mass index 36 (4.1) kg/m2, waist 104.8 (4.1) cm) participated in two separate, double-blind randomised experimental trials. Experiment 1 moderate exercise after α/ß adrenergic blocker (labetalol, 100 mg orally) versus moderate exercise plus placebo; experiment 2 adrenaline infusion for 20 minutes versus saline infusion. Appetite/satiety and biochemistry were measured at baseline, pre- and immediately post-intervention, then 1 hour post-intervention (i.e., before dinner). Food intake was assessed via ad libitum buffet-style dinner.RESULTS:
No differences were found in appetite/satiety, subsequent food intake or serum leptin in any of the studies (experiment 1 or experiment 2). In experiment 1, blood glucose was higher (p < 0.01) and plasma free fatty acids lower (p = 0.04) versus placebo. In experiment 2, plasma free fatty acids (p < 0.05) increased after adrenaline versus saline infusion.CONCLUSIONS:
Neither inhibition of exercise-induced adrenergic activity by combined α/ß adrenergic blockade nor moderate increases in adrenergic activity induced by intravenous adrenaline infusion affected acute appetite regulation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação do Apetite
/
Exercício Físico
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Epinefrina
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Adrenérgicos
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Labetalol
/
Obesidade
Tipo de estudo:
Clinical_trials
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Nutr Health
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido