Expression of DC-SIGN-like C-Type Lectin Receptors in Salmo salar.
Dev Comp Immunol
; 113: 103806, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-32739503
ABSTRACT
C-Type Lectin Receptors (CTLR) are involved in the activation of innate and adaptative immune responses. Among these receptors, the Dendritic Cell-Specific ICAM-3-Grabbing nonintegrin (DC-SIGN/CD209) has become a hot topic due to its ability to bind and facilitate the infections processes of several pathogens. Although well characterized in mammals, little documentation exists about the receptor in salmonid fishes. Here, we report the sequence and expression analysis of eight DC-SIGN-like genes in Salmo salar. Each receptor displays structural similarities to DC-SIGN molecules described in mammals, including internalization motifs, a neck region with heptad repeats, and a Ca+2-dependent carbohydrate recognition domain. The receptors are expressed in multiple tissues of fish, and fish cell lines, with differential expression upon infection with viral and bacterial pathogens. The identification of DC-SIGN-like receptors in Salmo salar provides new information regarding the structure of the immune system of salmon, potential markers for cell subsets, as well as insights into DC-SIGN conservation across species.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Moléculas de Adesão Celular
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Infecções por Orthomyxoviridae
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Receptores de Superfície Celular
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Salmo salar
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Proteínas de Peixes
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Lectinas Tipo C
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Infecções por Piscirickettsiaceae
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Isavirus
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Piscirickettsia
Limite:
Animals
Idioma:
En
Revista:
Dev Comp Immunol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Chile