Anti-HMGCR Specificity of HALIP: A Confirmatory Study.
J Immunol Res
; 2020: 6292631, 2020.
Article
em En
| MEDLINE
| ID: mdl-32766318
ABSTRACT
A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern). In this study, we furthered the original studies to demonstrate the association of anti-HMGCR antibodies with the HALIP. Human anti-HMGCR antibodies from patients' sera were purified and incubated with rat triple tissue (kidney/stomach/liver). A characteristic HALIP was observed. Additionally, a colocalization assay of human anti-HMGCR antibodies with rabbit polyclonal anti-HMGCR antibodies showed colocalization of both immunofluorescence patterns. This study confirms that the HALIP is due to human anti-HMGCR antibodies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Hidroximetilglutaril-CoA Redutases
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Immunol Res
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Espanha