Cancer-associated fibroblasts induce epithelial-mesenchymal transition and cisplatin resistance in ovarian cancer via CXCL12/CXCR4 axis.

Zhang, Fang; Cui, Jian-Ying; Gao, Hai-Feng; Yu, Hao; Gao, Fu-Feng; Chen, Jin-Long; Chen, Liang

Zhang, Fang; Cui, Jian-Ying; Gao, Hai-Feng; Yu, Hao; Gao, Fu-Feng; Chen, Jin-Long; Chen, Liang.

Afiliação

Zhang F; Department of Radiology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, PR China.
Cui JY; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, PR China.
Gao HF; Department of Obstetrics & Gynecology, Jiyang District People's Hospital of Jinan City, Jinan 251400, PR China.
Yu H; Department of Oncology, Dongying People's Hospital, Dongying, Shandong 257091, PR China.
Gao FF; Department of Gynecological Oncology, Shandong Cancer Hospital & Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, PR China.
Chen JL; Department of Gynecological Oncology, Shandong Cancer Hospital & Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, PR China.
Chen L; Department of Gynecological Oncology, Shandong Cancer Hospital & Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, PR China.

Future Oncol ; 16(32): 2619-2633, 2020 Nov.

Article em En | MEDLINE | ID: mdl-32804554

Assuntos

Fibroblastos Associados a Câncer/metabolismo; Carcinoma Epitelial do Ovário/metabolismo; Carcinoma Epitelial do Ovário/patologia; Quimiocina CXCL12/metabolismo; Resistencia a Medicamentos Antineoplásicos; Transição Epitelial-Mesenquimal; Receptores CXCR4/metabolismo; Microambiente Tumoral; Biomarcadores; Fibroblastos Associados a Câncer/efeitos dos fármacos; Fibroblastos Associados a Câncer/patologia; Carcinoma Epitelial do Ovário/etiologia; Linhagem Celular Tumoral; Cisplatino; Suscetibilidade a Doenças; Transição Epitelial-Mesenquimal/efeitos dos fármacos; Feminino; Humanos; Transdução de Sinais; Microambiente Tumoral/efeitos dos fármacos; Via de Sinalização Wnt

Palavras-chave

CAFs; CXCL12; CXCR4; EMT; Wnt; apoptosis; cisplatin resistance; ovarian cancer; ß-catenin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistencia a Medicamentos Antineoplásicos / Receptores CXCR4 / Quimiocina CXCL12 / Transição Epitelial-Mesenquimal / Microambiente Tumoral / Fibroblastos Associados a Câncer / Carcinoma Epitelial do Ovário Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Future Oncol Ano de publicação: 2020 Tipo de documento: Article

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