MAP30 protein from Momordica charantia is therapeutic and has synergic activity with cisplatin against ovarian cancer in vivo by altering metabolism and inducing ferroptosis.

Chan, David W; Yung, Mingo Mh; Chan, Yau-Sang; Xuan, Yang; Yang, Huijuan; Xu, Dakang; Zhan, Jin-Biao; Chan, Karen Kl; Ng, Tzi-Bun; Ngan, Hextan Ys

Chan, David W; Yung, Mingo Mh; Chan, Yau-Sang; Xuan, Yang; Yang, Huijuan; Xu, Dakang; Zhan, Jin-Biao; Chan, Karen Kl; Ng, Tzi-Bun; Ngan, Hextan Ys.

Afiliação

Chan DW; Department of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: dwchan@hku.hk.
Yung MM; Department of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
Chan YS; Department of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
Xuan Y; Department of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
Yang H; Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, PR China.
Xu D; Faculty of Medical Laboratory Science, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, PR China.
Zhan JB; Department of Biochemistry, Zhejiang University School of Medicine, 866 Yuhangtang Road, Zijingang Campus, Hangzhou, Zhejiang, 310058, PR China.
Chan KK; Department of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
Ng TB; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
Ngan HY; Department of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: hysngan@hku.hk.

Pharmacol Res ; 161: 105157, 2020 11.

Article em En | MEDLINE | ID: mdl-32814169

Assuntos

Antineoplásicos Fitogênicos/farmacologia; Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Cisplatino/farmacologia; Metabolismo Energético/efeitos dos fármacos; Ferroptose/efeitos dos fármacos; Momordica charantia; Neoplasias Ovarianas/tratamento farmacológico; Proteínas Inativadoras de Ribossomos Tipo 2/farmacologia; Proteínas Quinases Ativadas por AMP/metabolismo; Animais; Antineoplásicos Fitogênicos/isolamento & purificação; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Sinergismo Farmacológico; Feminino; Glicólise/efeitos dos fármacos; Humanos; Lipogênese/efeitos dos fármacos; Camundongos Endogâmicos BALB C; Camundongos Nus; Momordica charantia/química; Invasividade Neoplásica; Neoplasias Ovarianas/metabolismo; Neoplasias Ovarianas/patologia; Proteínas Inativadoras de Ribossomos Tipo 2/isolamento & purificação; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

A23187 (PubChem CID: 40486); AICAR (PubChem CID: 46780289); BODIPY (PubChem: CID: 25058173); Cisplatin (PubChem CID: 441203); Erastin (PubChem CID: 11214940); Ferrostatin 1 (PubChem CID: 4068248); MAP30; NaCl (PubChem CID: 5234); PVDF (PubChem CID: 3082294); Phenylmethylsulfonyl fluoride (PMSF) (PubChem CID: 4784); Propidium iodide (PI) (PubChem CID: 104981); STO-609 (PubChem CID: 3467590); Tris-HCl (PubChem CID: 93573); bitter melon; chemoresistance; ferroptosis; metabolism; ovarian cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Protocolos de Quimioterapia Combinada Antineoplásica / Cisplatino / Momordica charantia / Metabolismo Energético / Proteínas Inativadoras de Ribossomos Tipo 2 / Ferroptose / Antineoplásicos Fitogênicos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article

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