Your browser doesn't support javascript.
loading
Anti-Melanoma Activities and Phytochemical Compositions of Sorbus commixta Fruit Extracts.
Jin, Sora; Kim, Kyeoung Cheol; Kim, Ju-Sung; Jang, Keum-Il; Hyun, Tae Kyung.
Afiliação
  • Jin S; Department of Industrial Plant Science and Technology, College of Agricultural, Life and Environmental Sciences, Chungbuk National University, Cheongju 28644, Korea.
  • Kim KC; College of Agriculture & Life Sciences, SARI, Jeju National University, Jeju 63243, Korea.
  • Kim JS; College of Agriculture & Life Sciences, SARI, Jeju National University, Jeju 63243, Korea.
  • Jang KI; Department of Food Science and Biotechnology, College of Agricultural, Life and Environmental Sciences, Chungbuk National University, Cheongju 28644, Korea.
  • Hyun TK; Department of Industrial Plant Science and Technology, College of Agricultural, Life and Environmental Sciences, Chungbuk National University, Cheongju 28644, Korea.
Plants (Basel) ; 9(9)2020 Aug 21.
Article em En | MEDLINE | ID: mdl-32825598
ABSTRACT
Sorbus commixta Hedl. (Rosaceae family) has a long history as a medicinal plant in East Asian countries. In this study, we evaluated the effect of S. commixta fruit extracts prepared with different ethanol concentrations on anti-melanoma activity, and the extraction yield of phenolic compounds and flavonoids. Using the partitioned fractions from the EtOH extract, we found that the butanol fraction (BF) possessed strong cytotoxic activity against SK-MEL-2 cells (human melanoma cells) but not against HDFa cells (human dermal fibroblast adult cells). Additionally, BF-induced cell death was mediated by the inhibition of the mitogen-activated protein kinase/extracellular regulated kinase (MEK/ERK) signaling pathway, coupled with the upregulation of caspase-3 activity in SK-MEL-2 cells. Furthermore, HPLC analysis of polyphenolic compounds suggested that S. commixta fruits contained several active compounds including chlorogenic acid, rutin, protocatechuic acid, and hydroxybenzoic acid, all of which are known to possess anti-cancer activities. Although this study has been carried out by cell-based approach, these results suggest that S. commixta fruits contain promising anti-melanoma compounds.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Plants (Basel) Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Plants (Basel) Ano de publicação: 2020 Tipo de documento: Article