Ryanodine Receptors: A Potential Treatment Target in Various Neurodegenerative Disease.
Cell Mol Neurobiol
; 41(8): 1613-1624, 2021 Nov.
Article
em En
| MEDLINE
| ID: mdl-32833122
ABSTRACT
Progressive neuronal demise is a key contributor to the key pathogenic event implicated in many different neurodegenerative disorders (NDDs). There are several therapeutic strategies available; however, none of them are particularly effective. Targeted neuroprotective therapy is one such therapy, which seems a compelling option, yet remains challenging due to the internal heterogeneity of the mechanisms underlying various NDDs. An alternative method to treat NDDs is to exploit common modalities involving molecularly distinct subtypes and thus develop specialized drugs with broad-spectrum characteristics. There is mounting evidence which supports for the theory that dysfunctional ryanodine receptors (RyRs) disrupt intracellular Ca2+ homeostasis, contributing to NDDs significantly. This review aims to provide direct and indirect evidence on the intersection of NDDs and RyRs malfunction, and to shed light on novel strategies to treat RyRs-mediated disease, modifying pharmacological therapies such as the potential therapeutic role of dantrolene, a RyRs antagonist.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bloqueadores dos Canais de Cálcio
/
Doenças Neurodegenerativas
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Canal de Liberação de Cálcio do Receptor de Rianodina
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Sinalização do Cálcio
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Dantroleno
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Mol Neurobiol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos