Circular DNA intermediates in the generation of large human segmental duplications.
BMC Genomics
; 21(1): 593, 2020 Aug 26.
Article
em En
| MEDLINE
| ID: mdl-32847497
ABSTRACT
BACKGROUND:
Duplications of large genomic segments provide genetic diversity in genome evolution. Despite their importance, how these duplications are generated remains uncertain, particularly for distant duplicated genomic segments.RESULTS:
Here we provide evidence of the participation of circular DNA intermediates in the single generation of some large human segmental duplications. A specific reversion of sequence order from A-B/C-D to B-A/D-C between duplicated segments and the presence of only microhomologies and short indels at the evolutionary breakpoints suggest a circularization of the donor ancestral locus and an accidental replicative interaction with the acceptor locus.CONCLUSIONS:
This novel mechanism of random genomic mutation could explain several distant genomic duplications including some of the ones that took place during recent human evolution.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Circular
/
Duplicações Segmentares Genômicas
Limite:
Humans
Idioma:
En
Revista:
BMC Genomics
Assunto da revista:
GENETICA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Espanha