Can data from paediatric cohorts solve the COVID-19 puzzle?
PLoS Pathog
; 16(9): e1008798, 2020 09.
Article
em En
| MEDLINE
| ID: mdl-32903279
ABSTRACT
COVID-19, caused by SARS-CoV-2, is significantly more severe in adults than in children. The biological reasons for this difference remain to be elucidated. We have compared the most recent virological and immunological data related to COVID-19 between adults and children and contrasted this with earlier data from severe acute respiratory syndrome (SARS) caused by the related SARS-CoV-1 in 2003. Based on these available data, a number of hypotheses are proposed to explain the difference in COVID-19 clinical outcomes between adults and children. NF-kB may be a key factor that could explain the severe clinical manifestations of COVID-19 in adults as well as rare complications associated with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in paediatric COVID-19 patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
/
NF-kappa B
/
Fatores Etários
/
Infecções por Coronavirus
/
Betacoronavirus
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Child
/
Humans
Idioma:
En
Revista:
PLoS Pathog
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Austrália