Reduction in intestinal colonization and invasion of internal organs after challenge by homologous and heterologous serovars of Salmonella enterica following vaccination of chickens with a novel trivalent inactivated Salmonella vaccine.
Avian Pathol
; 49(6): 666-677, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-32907345
ABSTRACT
A novel inactivated vaccine, comprising three serovars of Salmonella enterica (Enteritidis, serogroup O9; Typhimurium, serogroup O4; Infantis, serogroup O7) grown under conditions of iron restriction and adjuvanted with aluminium hydroxide, was evaluated for efficacy following challenge by homologous and heterologous serovars. Chickens were vaccinated at 6 and 10 weeks of age by the intramuscular route and challenged 4 to 9 weeks after the second vaccination with serovars belonging to serogroup O9 (Enteritidis), O4 (Typhimurium and Heidelberg), O7 (Infantis and Virchow), and O8 (Hadar). All vaccinated birds produced a marked systemic antibody response against each of the component vaccine antigens by the time of challenge. Significant reductions in both colonization of the intestinal tract and invasion of internal organs were observed in vaccinated birds compared with non-vaccinated controls, irrespective of the challenge serovar. The findings suggest that broad serovar protection within the constitutive serogroups of an inactivated multi-valent vaccine is possible and could, therefore, play an important role in future Salmonella control programmes. RESEARCH HIGHLIGHTS Novel inactivated trivalent Salmonella chicken vaccine was developed and tested. Vaccine induced marked systemic antibody response against all vaccine antigens. Significant reductions in intestinal tract colonization and internal organ invasion. Vaccine efficacy demonstrated against homologous and heterologous serovars.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças das Aves Domésticas
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Salmonelose Animal
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Galinhas
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Vacinação
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Salmonella enterica
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Vacinas contra Salmonella
Limite:
Animals
Idioma:
En
Revista:
Avian Pathol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido