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Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer's Disease.
Li, Long; Li, Le; Zhang, Jiayong; Huang, Sheng; Liu, Weilin; Wang, Zhifu; Liang, Shengxiang; Tao, Jing; Chen, Lidian.
Afiliação
  • Li L; College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
  • Li L; Fujian Key Laboratory of Rehabilitation Technology, Fuzhou, Fujian 350122, China.
  • Zhang J; College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
  • Huang S; Fujian Key Laboratory of Rehabilitation Technology, Fuzhou, Fujian 350122, China.
  • Liu W; Fujian Key Laboratory of Rehabilitation Technology, Fuzhou, Fujian 350122, China.
  • Wang Z; Fujian Key Laboratory of Rehabilitation Technology, Fuzhou, Fujian 350122, China.
  • Liang S; National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
  • Tao J; College of Integrated Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
  • Chen L; National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
Neural Plast ; 2020: 8836173, 2020.
Article em En | MEDLINE | ID: mdl-32908486
Microglia are the primary cells that exert immune function in the central nervous system, and accumulating evidence suggests that microglia act as critical players in the initiation of neurodegenerative disorders, such as Alzheimer's disease (AD). Microglia seemingly demonstrate two contradictory phenotypes in response to different microenvironmental cues, the M1 phenotype and the M2 phenotype, which are detrimental and beneficial to pathogenesis, respectively. Inhibiting the M1 phenotype with simultaneous promoting the M2 phenotype has been suggested as a potential therapeutic approach for cure AD. In this study, we demonstrated that electroacupuncture at the Shenting and Baihui acupoints for 16 weeks could improve learning and memory in the Morris water maze test and reduce amyloid ß-protein in the parietal association cortex and entorhinal cortex in mice with mild and moderate AD. Besides, electroacupuncture at the Shenting and Baihui acupoints not only suppressed M1 marker (iNOS/IL-1ß) expression but also increased the M2 marker (CD206/Arg1) expression in those regions. We propose that electroacupuncture at the Shenting and Baihui acupoints could regulate microglial polarization and decrease Aß plaques to improve learning and memory in mild AD mice.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lobo Parietal / Eletroacupuntura / Polaridade Celular / Microglia / Aprendizagem em Labirinto / Córtex Entorrinal / Doença de Alzheimer Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Neural Plast Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lobo Parietal / Eletroacupuntura / Polaridade Celular / Microglia / Aprendizagem em Labirinto / Córtex Entorrinal / Doença de Alzheimer Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Neural Plast Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China