Nonpeptidic quinazolinone derivatives as dual nucleotide-binding oligomerization domain-like receptor 1/2 antagonists for adjuvant cancer chemotherapy.

Ma, Yao; Yang, Jingshu; Wei, Xiduan; Pei, Yameng; Ye, Jingjia; Li, Xueyuan; Si, Guangxu; Tian, Jingyuan; Dong, Yi; Liu, Gang

Ma, Yao; Yang, Jingshu; Wei, Xiduan; Pei, Yameng; Ye, Jingjia; Li, Xueyuan; Si, Guangxu; Tian, Jingyuan; Dong, Yi; Liu, Gang.

Afiliação

Ma Y; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2A Nanwei Rd, Xicheng Dist, Beijing, 100050, PR China.
Yang J; School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist, Beijing, 100084, PR China.
Wei X; School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist, Beijing, 100084, PR China.
Pei Y; School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist, Beijing, 100084, PR China.
Ye J; School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist, Beijing, 100084, PR China.
Li X; School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist, Beijing, 100084, PR China.
Si G; School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist, Beijing, 100084, PR China.
Tian J; School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist, Beijing, 100084, PR China.
Dong Y; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2A Nanwei Rd, Xicheng Dist, Beijing, 100050, PR China. Electronic address: dongyi@imm.ac.cn.
Liu G; School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist, Beijing, 100084, PR China. Electronic address: gangliu27@tsinghua.edu.cn.

Eur J Med Chem ; 207: 112723, 2020 Dec 01.

Article em En | MEDLINE | ID: mdl-32920426

Assuntos

Proteína Adaptadora de Sinalização NOD1/antagonistas & inibidores; Proteína Adaptadora de Sinalização NOD2/antagonistas & inibidores; Quinazolinonas/química; Quinazolinonas/farmacologia; Animais; Linhagem Celular; Descoberta de Drogas; Humanos; Masculino; Melanoma Experimental/tratamento farmacológico; Melanoma Experimental/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; NF-kappa B/metabolismo; Proteína Adaptadora de Sinalização NOD1/metabolismo; Proteína Adaptadora de Sinalização NOD2/metabolismo; Nucleotídeos/metabolismo

Palavras-chave

B16 tumor; Dual NOD1/2 antagonists; Quinazolinone; Retroamide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinazolinonas / Proteína Adaptadora de Sinalização NOD1 / Proteína Adaptadora de Sinalização NOD2 Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Ano de publicação: 2020 Tipo de documento: Article

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