Structural basis for the action of the drug trametinib at KSR-bound MEK.

Khan, Zaigham M; Real, Alexander M; Marsiglia, William M; Chow, Arthur; Duffy, Mary E; Yerabolu, Jayasudhan R; Scopton, Alex P; Dar, Arvin C

Khan, Zaigham M; Real, Alexander M; Marsiglia, William M; Chow, Arthur; Duffy, Mary E; Yerabolu, Jayasudhan R; Scopton, Alex P; Dar, Arvin C.

Afiliação

Khan ZM; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Real AM; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marsiglia WM; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chow A; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Duffy ME; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yerabolu JR; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Scopton AP; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dar AC; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Nature ; 588(7838): 509-514, 2020 12.

Article em En | MEDLINE | ID: mdl-32927473

Assuntos

Quinases de Proteína Quinase Ativadas por Mitógeno/química; Quinases de Proteína Quinase Ativadas por Mitógeno/metabolismo; Proteínas Quinases/química; Proteínas Quinases/metabolismo; Piridonas/química; Piridonas/farmacologia; Pirimidinonas/química; Pirimidinonas/farmacologia; Sequência de Aminoácidos; Animais; Sítios de Ligação/efeitos dos fármacos; Humanos; Camundongos; Quinases de Proteína Quinase Ativadas por Mitógeno/antagonistas & inibidores; Modelos Moleculares; Ligação Proteica/efeitos dos fármacos; Inibidores de Proteínas Quinases/química; Inibidores de Proteínas Quinases/farmacologia; Especificidade por Substrato; Quinases raf/química; Quinases raf/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Piridonas / Pirimidinonas / Quinases de Proteína Quinase Ativadas por Mitógeno Limite: Animals / Humans Idioma: En Revista: Nature Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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