Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides.

Geekiyanage, Hirosha; Rayatpisheh, Shima; Wohlschlegel, James A; Brown, Robert; Ambros, Victor

Geekiyanage, Hirosha; Rayatpisheh, Shima; Wohlschlegel, James A; Brown, Robert; Ambros, Victor.

Afiliação

Geekiyanage H; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605.
Rayatpisheh S; Department of Biological Chemistry, Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Wohlschlegel JA; Department of Biological Chemistry, Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Brown R; Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605.
Ambros V; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605; victor.ambros@umassmed.edu.

Proc Natl Acad Sci U S A ; 117(39): 24213-24223, 2020 09 29.

Article em En | MEDLINE | ID: mdl-32929008

Assuntos

Proteínas Argonautas/sangue; MicroRNAs/sangue; Esclerose Lateral Amiotrófica/líquido cefalorraquidiano; Proteínas Argonautas/líquido cefalorraquidiano; Pareamento de Bases; Estudos de Casos e Controles; Humanos; Imunoprecipitação; MicroRNAs/líquido cefalorraquidiano

Palavras-chave

AGO2; Argonaut; cerebrospinal fluid; extracellular microRNA; human plasma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Proteínas Argonautas Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article

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