Bayesian sparse heritability analysis with high-dimensional neuroimaging phenotypes.
Biostatistics
; 23(2): 467-484, 2022 04 13.
Article
em En
| MEDLINE
| ID: mdl-32948880
ABSTRACT
Heritability analysis plays a central role in quantitative genetics to describe genetic contribution to human complex traits and prioritize downstream analyses under large-scale phenotypes. Existing works largely focus on modeling single phenotype and currently available multivariate phenotypic methods often suffer from scaling and interpretation. In this article, motivated by understanding how genetic underpinning impacts human brain variation, we develop an integrative Bayesian heritability analysis to jointly estimate heritabilities for high-dimensional neuroimaging traits. To induce sparsity and incorporate brain anatomical configuration, we impose hierarchical selection among both regional and local measurements based on brain structural network and voxel dependence. We also use a nonparametric Dirichlet process mixture model to realize grouping among single nucleotide polymorphism-associated phenotypic variations, providing biological plausibility. Through extensive simulations, we show the proposed method outperforms existing ones in heritability estimation and heritable traits selection under various scenarios. We finally apply the method to two large-scale imaging genetics datasets the Alzheimer's Disease Neuroimaging Initiative and United Kingdom Biobank and show biologically meaningful results.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Alzheimer
/
Neuroimagem
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Biostatistics
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos