Base Editing Landscape Extends to Perform Transversion Mutation.

Molla, Kutubuddin A; Qi, Yiping; Karmakar, Subhasis; Baig, Mirza J

Molla, Kutubuddin A; Qi, Yiping; Karmakar, Subhasis; Baig, Mirza J.

Afiliação

Molla KA; Indian Council of Agricultural Research (ICAR)-National Rice Research Institute (NRRI), Cuttack-753006, India. Electronic address: kutubuddin.molla@icar.gov.in.
Qi Y; Department of Plant Science and Landscape Architecture, University of Maryland, College Park, MD 20742, USA; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD 20850, USA.
Karmakar S; Indian Council of Agricultural Research (ICAR)-National Rice Research Institute (NRRI), Cuttack-753006, India.
Baig MJ; Indian Council of Agricultural Research (ICAR)-National Rice Research Institute (NRRI), Cuttack-753006, India.

Trends Genet ; 36(12): 899-901, 2020 12.

Article em En | MEDLINE | ID: mdl-32951947

ABSTRACT

ABSTRACT

Base editors have drawn considerable academic and industrial attention in recent years because of their ability to alter single DNA bases with precision. However, the existing cytosine and adenine base editors can only install transition mutations. Three recent studies (Kurt et al.,Zhao et al., and Chen et al.) expand the base editing toolbox by developing cytosine transversion base editors.

Assuntos

Sistemas CRISPR-Cas; Edição de Genes; Adenina; Citosina; Mutação

Palavras-chave

C-to-G editing; CRISPR/Cas; agriculture; base editing; point mutation; therapeutics; transversion base editor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas CRISPR-Cas / Edição de Genes Idioma: En Revista: Trends Genet Assunto da revista: GENETICA Ano de publicação: 2020 Tipo de documento: Article

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