Progranulin Administration Attenuates ß-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis.

Guan, Zhangxin; Chen, Zuolong; Fu, Shumei; Dai, Linbin; Shen, Yong

Guan, Zhangxin; Chen, Zuolong; Fu, Shumei; Dai, Linbin; Shen, Yong.

Afiliação

Guan Z; Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Chen Z; Hefei National Laboratory for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, School of Life Sciences, University of Science and Technology of China, Hefei, China.
Fu S; Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Dai L; Hefei National Laboratory for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, School of Life Sciences, University of Science and Technology of China, Hefei, China.
Shen Y; Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Front Cell Neurosci ; 14: 260, 2020.

Article em En | MEDLINE | ID: mdl-32973454

Palavras-chave

Alzheimer's disease; Aß; BACE1; microglia; progranulin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Cell Neurosci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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