Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer.
J Exp Med
; 166(1): 219-34, 1987 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-3298525
ABSTRACT
Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals. Several monkeys fully reconstituted and were shown to express the h-ADA and neor genes at low levels in their recirculating hematopoietic cells for short periods of time.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retroviridae
/
Transformação Genética
/
Adenosina Desaminase
/
Nucleosídeo Desaminases
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1987
Tipo de documento:
Article