Assessment of Amphiphilic Poly-<i>N</i>-vinylpyrrolidone Nanoparticles' Biocompatibility with Endothelial Cells <i>in Vitro</i> and Delivery of an Anti-Inflammatory Drug.

Berdiaki, Aikaterini; Perisynaki, Emmanouela; Stratidakis, Antonios; Kulikov, Pavel P; Kuskov, Andrey N; Stivaktakis, Polychronis; Henrich-Noack, Petra; Luss, Anna L; Shtilman, Mikhail M; Tzanakakis, George N; Tsatsakis, Aristidis; Nikitovic, Dragana

Assessment of Amphiphilic Poly-N-vinylpyrrolidone Nanoparticles' Biocompatibility with Endothelial Cells in Vitro and Delivery of an Anti-Inflammatory Drug.

Berdiaki, Aikaterini; Perisynaki, Emmanouela; Stratidakis, Antonios; Kulikov, Pavel P; Kuskov, Andrey N; Stivaktakis, Polychronis; Henrich-Noack, Petra; Luss, Anna L; Shtilman, Mikhail M; Tzanakakis, George N; Tsatsakis, Aristidis; Nikitovic, Dragana.

Afiliação

Berdiaki A; Laboratory of Histology-Embryology, School of Medicine, University of Crete, Voutes, 71003 Heraklion, Greece.
Perisynaki E; Laboratory of Histology-Embryology, School of Medicine, University of Crete, Voutes, 71003 Heraklion, Greece.
Stratidakis A; Institute for Advanced Study (IUSS), Environmental Health Engineering, Piazzadella Vittoria 15, 27100 Pavia, Italy.
Kulikov PP; Laboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Kuskov AN; Department of Biomaterials, D. Mendeleev University of Chemical Technology of Russia, Miusskaya Square 9, Moscow 125047, Russian Federation.
Stivaktakis P; Centre for Strategic Planning of FMBA of Russia, Moscow 119121, Russia.
Henrich-Noack P; Department of Biomaterials, D. Mendeleev University of Chemical Technology of Russia, Miusskaya Square 9, Moscow 125047, Russian Federation.
Luss AL; Laboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Shtilman MM; Clinic of Neurology with Institute of Translational Neurology, University Clinic Muenster, 48149 Muenster, Germany.
Tzanakakis GN; Department of Biomaterials, D. Mendeleev University of Chemical Technology of Russia, Miusskaya Square 9, Moscow 125047, Russian Federation.
Tsatsakis A; Department of Biomaterials, D. Mendeleev University of Chemical Technology of Russia, Miusskaya Square 9, Moscow 125047, Russian Federation.
Nikitovic D; Laboratory of Histology-Embryology, School of Medicine, University of Crete, Voutes, 71003 Heraklion, Greece.

Mol Pharm ; 17(11): 4212-4225, 2020 11 02.

Article em En | MEDLINE | ID: mdl-32986447

Assuntos

Anti-Inflamatórios/administração & dosagem; Materiais Biocompatíveis/química; Portadores de Fármacos/química; Células Endoteliais/efeitos dos fármacos; Indometacina/administração & dosagem; Nanopartículas/química; Polímeros/química; Pirrolidinonas/química; Anti-Inflamatórios/metabolismo; Linhagem Celular; Sobrevivência Celular/efeitos dos fármacos; Células Endoteliais/metabolismo; Fluoresceína-5-Isotiocianato/administração & dosagem; Corantes Fluorescentes/administração & dosagem; Corantes Fluorescentes/metabolismo; Humanos; Interações Hidrofóbicas e Hidrofílicas; Indometacina/metabolismo; Peso Molecular; Tamanho da Partícula

Palavras-chave

amphiphilic polymer; assessment; endothelial cells; fluorescent probes; immunological activation; nanoparticle; poly-N-vinylpyrrolidone; viability

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polímeros / Pirrolidinonas / Materiais Biocompatíveis / Portadores de Fármacos / Indometacina / Células Endoteliais / Nanopartículas / Anti-Inflamatórios Limite: Humans Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Grécia

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