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Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells.
Aliotta, Federica; Nasso, Rosarita; Rullo, Rosario; Arcucci, Alessandro; Avagliano, Angelica; Simonetti, Martina; Sanità, Gennaro; Masullo, Mariorosario; Lavecchia, Antonio; Ruocco, Maria Rosaria; Vendittis, Emmanuele De.
Afiliação
  • Aliotta F; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.
  • Nasso R; Department of Movement Sciences and Wellness, University of Naples "Parthenope", Naples, Italy.
  • Rullo R; Institute for the Animal Production Systems in the Mediterranean Environment, CNR, Naples, Italy.
  • Arcucci A; Department of Public Health, University of Naples Federico II, Naples, Italy.
  • Avagliano A; Department of Public Health, University of Naples Federico II, Naples, Italy.
  • Simonetti M; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.
  • Sanità G; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.
  • Masullo M; Department of Movement Sciences and Wellness, University of Naples "Parthenope", Naples, Italy.
  • Lavecchia A; Department of Pharmacy, "Drug Discovery" Laboratory, University of Naples Federico II, Naples, Italy.
  • Ruocco MR; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.
  • Vendittis E; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.
J Enzyme Inhib Med Chem ; 35(1): 1866-1878, 2020 Dec.
Article em En | MEDLINE | ID: mdl-32990107
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatases cdc25 / Inibidores Enzimáticos / Compostos de Anilina / Melanoma / Antineoplásicos Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatases cdc25 / Inibidores Enzimáticos / Compostos de Anilina / Melanoma / Antineoplásicos Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália