Single-Cell Analysis Reveals Heterogeneity of Virus Infection, Pathogenicity, and Host Responses: HIV as a Pioneering Example.
Annu Rev Virol
; 7(1): 333-350, 2020 09 29.
Article
em En
| MEDLINE
| ID: mdl-32991268
ABSTRACT
While analyses of cell populations provide averaged information about viral infections, single-cell analyses offer individual consideration, thereby revealing a broad spectrum of diversity as well as identifying extreme phenotypes that can be exploited to further understand the complex virus-host interplay. Single-cell technologies applied in the context of human immunodeficiency virus (HIV) infection proved to be valuable tools to help uncover specific biomarkers as well as novel candidate players in virus-host interactions. This review aims at providing an updated overview of single-cell analyses in the field of HIV and acquired knowledge on HIV infection, latency, and host response. Although HIV is a pioneering example, similar single-cell approaches have proven to be valuable for elucidating the behavior and virus-host interplay in a range of other viruses.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Replicação Viral
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Viroses
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HIV-1
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Latência Viral
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Análise de Célula Única
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Interações entre Hospedeiro e Microrganismos
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Virol
Ano de publicação:
2020
Tipo de documento:
Article