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First report of t(5;11) KMT2A-MAML1 fusion in de novo infant acute lymphoblastic leukemia.
Tandon, Sneha; Shago, Mary; Davidson, Scott; Kanwar, Nisha; Fuligni, Fabio; Shlien, Adam; Whitlock, James; Villani, Anita; Abla, Oussama.
Afiliação
  • Tandon S; Division of Hematology and Oncology, University Hospital Southampton, United Kingdom. Electronic address: Sneha.tandon@uhs.nhs.uk.
  • Shago M; The Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.
  • Davidson S; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.
  • Kanwar N; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.
  • Fuligni F; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.
  • Shlien A; The Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.
  • Whitlock J; Division of Pediatrics Hematology/Oncology, The Hospital for Sick Children; Department of Pediatrics, University of Toronto, Toronto, Canada.
  • Villani A; Division of Pediatrics Hematology/Oncology, The Hospital for Sick Children; Department of Pediatrics, University of Toronto, Toronto, Canada.
  • Abla O; Division of Pediatrics Hematology/Oncology, The Hospital for Sick Children; Department of Pediatrics, University of Toronto, Toronto, Canada.
Cancer Genet ; 248-249: 31-33, 2020 10.
Article em En | MEDLINE | ID: mdl-32992102
ABSTRACT
Infant acute lymphoblastic leukemia (ALL) comprises 2.5%-5% of pediatric ALL with inferior survival compared to older children. A majority of infants (80%) with ALL harbor KMT2A gene rearrangement, which portends a poor prognosis. Approximately 94 different partner genes have been identified to date. The common rearrangements include t(4;11)(q21;q23)KMT2A-AFF1,t(11;19) (q23;p13.3)KMT2A-MLLT1 and t(9;11)(p22;q23)KMT2A-MLLT3. We report a novel translocation t(5;11)(q35;q23)KMT2A-MAML1 in newly diagnosed infant precursor B-ALL. Long-term follow-up and a larger number of patients are needed to better understand its prognostic significance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Translocação Genética / Cromossomos Humanos Par 5 / Cromossomos Humanos Par 11 / Leucemia-Linfoma Linfoblástico de Células Precursoras B / Proteínas de Fusão Oncogênica / Histona-Lisina N-Metiltransferase / Proteínas de Ligação a DNA / Proteína de Leucina Linfoide-Mieloide Tipo de estudo: Prognostic_studies Limite: Humans / Infant / Male Idioma: En Revista: Cancer Genet Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Translocação Genética / Cromossomos Humanos Par 5 / Cromossomos Humanos Par 11 / Leucemia-Linfoma Linfoblástico de Células Precursoras B / Proteínas de Fusão Oncogênica / Histona-Lisina N-Metiltransferase / Proteínas de Ligação a DNA / Proteína de Leucina Linfoide-Mieloide Tipo de estudo: Prognostic_studies Limite: Humans / Infant / Male Idioma: En Revista: Cancer Genet Ano de publicação: 2020 Tipo de documento: Article