Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors.

Wang, Lulu; Yang, Lin; Wang, Chen; Zhao, Wei; Ju, Zhenlin; Zhang, Wei; Shen, Jianfeng; Peng, Yang; An, Clemens; Luu, Yen T; Song, Shumei; Yap, Timothy A; Ajani, Jaffer A; Mills, Gordon B; Shen, Xuetong; Peng, Guang

Wang, Lulu; Yang, Lin; Wang, Chen; Zhao, Wei; Ju, Zhenlin; Zhang, Wei; Shen, Jianfeng; Peng, Yang; An, Clemens; Luu, Yen T; Song, Shumei; Yap, Timothy A; Ajani, Jaffer A; Mills, Gordon B; Shen, Xuetong; Peng, Guang.

Afiliação

Wang L; Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Yang L; Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Wang C; Department of Medical Oncology, Tongji Hospital, The University of Huazhong Science & Technology, Wuhan, China.
Zhao W; Department of Systems Biology.
Ju Z; Department of Systems Biology.
Zhang W; Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Shen J; Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Peng Y; Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
An C; Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Luu YT; Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Song S; Department of Gastrointestinal Medical Oncology, and.
Yap TA; Department of Investigational Cancer Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Ajani JA; Department of Gastrointestinal Medical Oncology, and.
Mills GB; Department of Cell Development and Cancer Biology, Oregon Health and Science University, Knight Cancer Institute, Portland, Oregon, USA.
Shen X; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Peng G; Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

J Clin Invest ; 130(11): 5951-5966, 2020 11 02.

Article em En | MEDLINE | ID: mdl-33016929

Assuntos

Proteínas Mutadas de Ataxia Telangiectasia/metabolismo; Quinase do Ponto de Checagem 2/metabolismo; Proteínas de Ligação a DNA/deficiência; Proteínas de Membrana/metabolismo; Proteínas de Neoplasias; Neoplasias; Nucleotidiltransferases/metabolismo; Transdução de Sinais; Fatores de Transcrição/deficiência; Animais; Proteínas Mutadas de Ataxia Telangiectasia/genética; Quinase do Ponto de Checagem 2/genética; Proteínas de Ligação a DNA/metabolismo; Células HCT116; Humanos; Proteínas de Membrana/genética; Camundongos; Proteínas de Neoplasias/genética; Proteínas de Neoplasias/metabolismo; Neoplasias/genética; Neoplasias/metabolismo; Neoplasias/patologia; Nucleotidiltransferases/genética; Proteólise; Fatores de Transcrição/metabolismo

Palavras-chave

Cancer; Cancer immunotherapy; Cell Biology; Immunology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Transdução de Sinais / Proteínas de Ligação a DNA / Proteínas Mutadas de Ataxia Telangiectasia / Quinase do Ponto de Checagem 2 / Proteínas de Membrana / Proteínas de Neoplasias / Neoplasias / Nucleotidiltransferases Limite: Animals / Humans Idioma: En Revista: J Clin Invest Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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