Assembly Mechanism of Mucin and von Willebrand Factor Polymers.

Javitt, Gabriel; Khmelnitsky, Lev; Albert, Lis; Bigman, Lavi Shlomo; Elad, Nadav; Morgenstern, David; Ilani, Tal; Levy, Yaakov; Diskin, Ron; Fass, Deborah

Javitt, Gabriel; Khmelnitsky, Lev; Albert, Lis; Bigman, Lavi Shlomo; Elad, Nadav; Morgenstern, David; Ilani, Tal; Levy, Yaakov; Diskin, Ron; Fass, Deborah.

Afiliação

Javitt G; Department of Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Khmelnitsky L; Department of Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Albert L; Department of Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Bigman LS; Department of Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Elad N; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot 7610001, Israel.
Morgenstern D; De Botton Institute for Protein Profiling, Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot 7610001, Israel.
Ilani T; Department of Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Levy Y; Department of Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Diskin R; Department of Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Fass D; Department of Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: deborah.fass@weizmann.ac.il.

Cell ; 183(3): 717-729.e16, 2020 10 29.

Article em En | MEDLINE | ID: mdl-33031746

Assuntos

Biopolímeros/metabolismo; Mucinas/metabolismo; Fator de von Willebrand/metabolismo; Sequência de Aminoácidos; Animais; Microscopia Crioeletrônica; Dissulfetos/metabolismo; Feminino; Glicosilação; Células HEK293; Humanos; Concentração de Íons de Hidrogênio; Camundongos Endogâmicos C57BL; Modelos Moleculares; Mucinas/química; Mucinas/ultraestrutura; Peptídeos/química; Domínios Proteicos; Multimerização Proteica; Fator de von Willebrand/química; Fator de von Willebrand/ultraestrutura

Palavras-chave

O-glycosylation; X-ray crystallography; cryo-EM; disulfide bonds; mucins; mucus; polymer; protein assembly; quaternary structure; von Willebrand factor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biopolímeros / Fator de von Willebrand / Mucinas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cell Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Israel

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