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The use of a MITO-Porter to deliver exogenous therapeutic RNA to a mitochondrial disease's cell with a A1555G mutation in the mitochondrial 12S rRNA gene results in an increase in mitochondrial respiratory activity.
Yamada, Yuma; Maruyama, Minako; Kita, Tomoko; Usami, Shin-Ichi; Kitajiri, Shin-Ichiro; Harashima, Hideyoshi.
Afiliação
  • Yamada Y; Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-ku, Sapporo 060-0812, Japan. Electronic address: u-ma@pharm.hokudai.ac.jp.
  • Maruyama M; Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
  • Kita T; Center for iPS Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan; Department of Otolaryngology, Head and Neck Surgery, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyoku, Kyoto 606-8507 Japan.
  • Usami SI; School of Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
  • Kitajiri SI; School of Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
  • Harashima H; Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-ku, Sapporo 060-0812, Japan. Electronic address: harasima@pharm.hokudai.ac.jp.
Mitochondrion ; 55: 134-144, 2020 11.
Article em En | MEDLINE | ID: mdl-33035688
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Ribossômico / Doenças Mitocondriais / Mitocôndrias / Mutação Limite: Humans Idioma: En Revista: Mitochondrion Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Ribossômico / Doenças Mitocondriais / Mitocôndrias / Mutação Limite: Humans Idioma: En Revista: Mitochondrion Ano de publicação: 2020 Tipo de documento: Article