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Non-motor symptom burden in patients with Parkinson's disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort.
Jesús, S; Labrador-Espinosa, M A; Adarmes, A D; Méndel-Del Barrio, C; Martínez-Castrillo, J C; Alonso-Cánovas, A; Sánchez Alonso, P; Novo-Ponte, S; Alonso-Losada, M G; López Ariztegui, N; Segundo Rodríguez, J C; Morales, M I; Gastón, I; Lacruz Bescos, F; Clavero Ibarra, P; Kulisevsky, J; Pagonabarraga, J; Pascual-Sedano, B; Martínez-Martín, P; Santos-García, D; Mir, P.
Afiliação
  • Jesús S; Unidad de Trastornos del Movimiento, Servicio de Neurología Y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Av. Manuel Siurot s/n. 41013, Seville, Spain.
  • Labrador-Espinosa MA; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
  • Adarmes AD; Unidad de Trastornos del Movimiento, Servicio de Neurología Y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Av. Manuel Siurot s/n. 41013, Seville, Spain.
  • Méndel-Del Barrio C; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
  • Martínez-Castrillo JC; Unidad de Trastornos del Movimiento, Servicio de Neurología Y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Av. Manuel Siurot s/n. 41013, Seville, Spain.
  • Alonso-Cánovas A; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
  • Sánchez Alonso P; Unidad de Trastornos del Movimiento, Servicio de Neurología Y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Av. Manuel Siurot s/n. 41013, Seville, Spain.
  • Novo-Ponte S; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
  • Alonso-Losada MG; Hospital Universitario Ramón Y Cajal, Madrid, Spain.
  • López Ariztegui N; Hospital Universitario Ramón Y Cajal, Madrid, Spain.
  • Segundo Rodríguez JC; Hospital Universitario Puerta del Hierro, Madrid, Spain.
  • Morales MI; Hospital Universitario Puerta del Hierro, Madrid, Spain.
  • Gastón I; Hospital Meixoeiro, Complejo Hospitalario Universitario de Vigo, Vigo, Spain.
  • Lacruz Bescos F; Complejo Hospitalario de Toledo, Toledo, Spain.
  • Clavero Ibarra P; Complejo Hospitalario de Toledo, Toledo, Spain.
  • Kulisevsky J; Complejo Hospitalario de Toledo, Toledo, Spain.
  • Pagonabarraga J; Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain.
  • Pascual-Sedano B; Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain.
  • Martínez-Martín P; Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain.
  • Santos-García D; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
  • Mir P; Unidad de Trastornos del Movimiento, Servicio de Neurología, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Sci Rep ; 10(1): 16893, 2020 10 09.
Article em En | MEDLINE | ID: mdl-33037247
The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson's disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Comportamento Compulsivo / Transtornos Disruptivos, de Controle do Impulso e da Conduta / Comportamento Impulsivo Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Comportamento Compulsivo / Transtornos Disruptivos, de Controle do Impulso e da Conduta / Comportamento Impulsivo Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha