Your browser doesn't support javascript.
loading
Subependymal giant cell astrocytomas are characterized by mTORC1 hyperactivation, a very low somatic mutation rate, and a unique gene expression profile.
Giannikou, Krinio; Zhu, Zachary; Kim, Jaegil; Winden, Kellen D; Tyburczy, Magdalena E; Marron, David; Parker, Joel S; Hebert, Zachary; Bongaarts, Anika; Taing, Len; Long, Henry W; Pisano, William V; Alexandrescu, Sanda; Godlewski, Brianna; Nellist, Mark; Kotulska, Katarzyna; Jozwiak, Sergiusz; Roszkowski, Marcin; Mandera, Marek; Thiele, Elizabeth A; Lidov, Hart; Getz, Gad; Devinsky, Orrin; Lawrence, Michael S; Ligon, Keith L; Ellison, David W; Sahin, Mustafa; Aronica, Eleonora; Meredith, David M; Kwiatkowski, David J.
Afiliação
  • Giannikou K; Cancer Genetics Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. kgiannikou@bwh.harvard.edu.
  • Zhu Z; Broad Institute of MIT and Harvard, Cancer Genome Program, Cambridge, MA, USA. kgiannikou@bwh.harvard.edu.
  • Kim J; Cancer Genetics Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Winden KD; Broad Institute of MIT and Harvard, Cancer Genome Program, Cambridge, MA, USA.
  • Tyburczy ME; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Marron D; Cancer Genetics Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Parker JS; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Hebert Z; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Bongaarts A; Molecular Biology Core Facility, Dana Farber Cancer Institute, Boston, MA, USA.
  • Taing L; Amsterdam UMC, University of Amsterdam, Department of (Neuro)Pathology, Amsterdam Neuroscience, Amsterdam, the Netherlands.
  • Long HW; Center for Functional Cancer Epigenetics, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
  • Pisano WV; Center for Functional Cancer Epigenetics, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
  • Alexandrescu S; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Godlewski B; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Nellist M; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Kotulska K; Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands.
  • Jozwiak S; Department of Child Neurology, Medical University of Warsaw, Warsaw, Poland.
  • Roszkowski M; Department of Child Neurology, Medical University of Warsaw, Warsaw, Poland.
  • Mandera M; Department of Neurosurgery, The Children's Memorial Health Institute, Warsaw, Poland.
  • Thiele EA; Department of Pediatric Neurosurgery, Medical University of Silesia, Katowice, Poland.
  • Lidov H; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
  • Getz G; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Devinsky O; Broad Institute of MIT and Harvard, Cancer Genome Program, Cambridge, MA, USA.
  • Lawrence MS; Department of Neurology, New York University School of Medicine, 223 E 34 Street, New York, NY, USA.
  • Ligon KL; Broad Institute of MIT and Harvard, Massachusetts General Hospital Cancer Center, Department of Pathology, Harvard Medical School, Charlestown, MA, USA.
  • Ellison DW; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Sahin M; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Aronica E; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Meredith DM; Amsterdam UMC, University of Amsterdam, Department of (Neuro)Pathology, Amsterdam Neuroscience, Amsterdam, the Netherlands.
  • Kwiatkowski DJ; Stichting Epilepsie Instellingen Nederland (SEIN), Zwolle, The Netherlands.
Mod Pathol ; 34(2): 264-279, 2021 02.
Article em En | MEDLINE | ID: mdl-33051600
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Astrocitoma / Neoplasias Encefálicas / Alvo Mecanístico do Complexo 1 de Rapamicina / Proteína 1 do Complexo Esclerose Tuberosa / Proteína 2 do Complexo Esclerose Tuberosa Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: Mod Pathol Assunto da revista: PATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Astrocitoma / Neoplasias Encefálicas / Alvo Mecanístico do Complexo 1 de Rapamicina / Proteína 1 do Complexo Esclerose Tuberosa / Proteína 2 do Complexo Esclerose Tuberosa Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: Mod Pathol Assunto da revista: PATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos