Ependymoma and Chordoma.
Neurosurgery
; 87(5): 860-870, 2020 10 15.
Article
em En
| MEDLINE
| ID: mdl-33057707
ABSTRACT
Ependymoma and chordoma are 2 tumors that occur throughout the craniospinal axis, and for which the extent of neurosurgical resection has a key prognostic role. Both tumors have distinctive pathologic features, yet can present significant diagnostic challenges to pathologists in cases without classical histology. The molecular understanding of ependymoma has had significant advances in the past decade, with the identification of 9 molecular groups with significant prognostic and clinical implications, while a comprehensive study of chordoma further emphasized the key role of brachyury overexpression in its pathogenesis. In this review, we discuss the pathogenesis, radiology and gross pathology, histology, and molecular features of these 2 tumors, as well as active research into targeted therapies, with an emphasis on practical diagnostic challenges, and the use of immunohistochemical and molecular tests in routine diagnostic practice.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cordoma
/
Neoplasias do Sistema Nervoso Central
/
Ependimoma
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neurosurgery
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Canadá