A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis.

Sanchis, Paula; Fernández-Gayol, Olaya; Comes, Gemma; Aguilar, Kevin; Escrig, Anna; Giralt, Mercedes; Palmiter, Richard D; Hidalgo, Juan

Sanchis, Paula; Fernández-Gayol, Olaya; Comes, Gemma; Aguilar, Kevin; Escrig, Anna; Giralt, Mercedes; Palmiter, Richard D; Hidalgo, Juan.

Afiliação

Sanchis P; Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193, Barcelona, Spain.
Fernández-Gayol O; Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193, Barcelona, Spain.
Comes G; Current affiliation: Department of Pediatrics, Division of Molecular Genetics, Columbia University Irving Medical Center, New York, 10032, USA.
Aguilar K; Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193, Barcelona, Spain.
Escrig A; Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193, Barcelona, Spain.
Giralt M; Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193, Barcelona, Spain.
Palmiter RD; Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193, Barcelona, Spain.
Hidalgo J; Department of Biochemistry, Genome Sciences, and Howard Hughes Medical Institute, University of Washington, Seattle, WA, 98195, USA.

J Neuroinflammation ; 17(1): 304, 2020 Oct 15.

Article em En | MEDLINE | ID: mdl-33059703

Assuntos

Modelos Animais de Doenças; Encefalomielite Autoimune Experimental/metabolismo; Integrases/biossíntese; Interleucina-6/biossíntese; Microglia/metabolismo; Sequência de Aminoácidos; Animais; Encefalomielite Autoimune Experimental/induzido quimicamente; Encefalomielite Autoimune Experimental/patologia; Expressão Gênica; Integrases/genética; Interleucina-6/deficiência; Interleucina-6/genética; Lipopolissacarídeos/toxicidade; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Microglia/patologia

Palavras-chave

Conditional reversible IL-6 knockout; DIO technology; Experimental autoimmune encephalomyelitis; Microglial IL-6

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-6 / Microglia / Integrases / Modelos Animais de Doenças / Encefalomielite Autoimune Experimental Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Neuroinflammation Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha

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