Protocol description of the HOVON 141/VISION trial: a prospective, multicentre, randomised phase II trial of ibrutinib plus venetoclax in patients with creatinine clearance &#8805;30 mL/min who have relapsed or refractory chronic lymphocytic leukaemia (RR-CLL) with or without TP53 aberrations.

Levin, Mark-David; Kater, Arnon P; Mattsson, Mattias; Kersting, Sabina; Ranti, Juha; Thi Tuyet Tran, Hoa; Nasserinejad, Kazem; Niemann, Carsten Utoft

Protocol description of the HOVON 141/VISION trial: a prospective, multicentre, randomised phase II trial of ibrutinib plus venetoclax in patients with creatinine clearance ≥30 mL/min who have relapsed or refractory chronic lymphocytic leukaemia (RR-CLL) with or without TP53 aberrations.

Levin, Mark-David; Kater, Arnon P; Mattsson, Mattias; Kersting, Sabina; Ranti, Juha; Thi Tuyet Tran, Hoa; Nasserinejad, Kazem; Niemann, Carsten Utoft.

Afiliação

Levin MD; Department of Internal Medicine, Albert Schweitzer Hospital Location Dordwijk, Dordrecht, Zuid-Holland, The Netherlands.
Kater AP; Department of Hematology, Amsterdam UMC - Locatie AMC, Amsterdam, North Holland, The Netherlands a.p.kater@amsterdamumc.nl.
Mattsson M; Department of Hematology, Uppsala Universitet, Uppsala, Sweden.
Kersting S; Department of Hematology, Haga Hospital, Den Haag, Zuid-Holland, The Netherlands.
Ranti J; Department of Hematology, University of Turku, Turku, Finland.
Thi Tuyet Tran H; Department of Hematology, Akershus University Hospital, Lorenskog, Norway.
Nasserinejad K; HOVON Data Center, Department of Hematology, Erasmus MC, Rotterdam, Zuid-Holland, The Netherlands.
Niemann CU; Department of Hematology, Rigshospitalet, Copenhagen, Denmark.

BMJ Open ; 10(10): e039168, 2020 10 15.

Article em En | MEDLINE | ID: mdl-33060089

Assuntos

Adenina/análogos & derivados; Leucemia Linfocítica Crônica de Células B; Piperidinas; Adenina/uso terapêutico; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico; Compostos Bicíclicos Heterocíclicos com Pontes; Creatinina; Humanos; Leucemia Linfocítica Crônica de Células B/tratamento farmacológico; Piperidinas/uso terapêutico; Estudos Prospectivos; Receptores Órfãos Semelhantes a Receptor Tirosina Quinase; Recidiva; Sulfonamidas; Proteína Supressora de Tumor p53

Palavras-chave

clinical trials; leukaemia; lymphoma; toxicity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Adenina / Leucemia Linfocítica Crônica de Células B Tipo de estudo: Clinical_trials / Guideline / Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: BMJ Open Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda

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