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Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype-Derived Activity Scores.
Thomas, Cameron D; Mosley, Scott A; Kim, Sarah; Lingineni, Karthik; El Rouby, Nihal; Langaee, Taimour Y; Gong, Yan; Wang, Danxin; Schmidt, Siegfried O; Binkley, Philip F; Estores, David S; Feng, Kairui; Kim, Hyewon; Kinjo, Minori; Li, Zhichuan; Fang, Lanyan; Chapman, Arlene B; Cooper-DeHoff, Rhonda M; Gums, John G; Hamadeh, Issam S; Zhao, Liang; Schmidt, Stephan; Frye, Reginald F; Johnson, Julie A; Cavallari, Larisa H.
Afiliação
  • Thomas CD; Department of Pharmacotherapy and Translation Research, Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
  • Mosley SA; Department of Pharmacotherapy and Translation Research, Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
  • Kim S; Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA.
  • Lingineni K; Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA.
  • El Rouby N; Department of Pharmacotherapy and Translation Research, Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
  • Langaee TY; Department of Pharmacotherapy and Translation Research, Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
  • Gong Y; Department of Pharmacotherapy and Translation Research, Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
  • Wang D; Department of Pharmacotherapy and Translation Research, Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
  • Schmidt SO; Department of Community Health and Family Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA.
  • Binkley PF; Department of Cardiovascular Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
  • Estores DS; Division of Gastroenterology, Hepatology & Nutrition, College of Medicine, University of Florida, Gainesville, Florida, USA.
  • Feng K; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
  • Kim H; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
  • Kinjo M; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
  • Li Z; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
  • Fang L; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
  • Chapman AB; Biological Sciences Division, The University of Chicago, Chicago, Illinois, USA.
  • Cooper-DeHoff RM; Department of Pharmacotherapy and Translation Research, Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
  • Gums JG; Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA.
  • Hamadeh IS; Department of Pharmacotherapy and Translation Research, Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
  • Zhao L; Department of Pharmacotherapy and Translation Research, Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
  • Schmidt S; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
  • Frye RF; Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA.
  • Johnson JA; Department of Pharmacotherapy and Translation Research, Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
  • Cavallari LH; Department of Pharmacotherapy and Translation Research, Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
CPT Pharmacometrics Syst Pharmacol ; 9(12): 678-685, 2020 12.
Article em En | MEDLINE | ID: mdl-33067866
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocromo P-450 CYP2D6 / Antagonistas de Receptores Adrenérgicos beta 1 / Genótipo / Metoprolol Tipo de estudo: Clinical_trials / Guideline / Observational_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: CPT Pharmacometrics Syst Pharmacol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocromo P-450 CYP2D6 / Antagonistas de Receptores Adrenérgicos beta 1 / Genótipo / Metoprolol Tipo de estudo: Clinical_trials / Guideline / Observational_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: CPT Pharmacometrics Syst Pharmacol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos