The contribution of uncoupling protein 2 to mitochondrial Ca2+ homeostasis in health and disease - A short revisit.
Mitochondrion
; 55: 164-173, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-33069910
ABSTRACT
Considering the versatile functions attributed to uncoupling protein 2 (UCP2) in health and disease, a profound understanding of the protein's molecular actions under physiological and pathophysiological conditions is indispensable. This review aims to revisit and shed light on the fundamental molecular functions of UCP2 in mitochondria, with particular emphasis on its intricate role in regulating mitochondrial calcium (Ca2+) uptake. UCP2's modulating effect on various vital processes in mitochondria makes it a crucial regulator of mitochondrial homeostasis in health and disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cálcio
/
Doenças Mitocondriais
/
Proteína Desacopladora 2
/
Mitocôndrias
Limite:
Humans
Idioma:
En
Revista:
Mitochondrion
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Áustria