In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice.

Rodríguez-Matellán, Alberto; Alcazar, Noelia; Hernández, Félix; Serrano, Manuel; Ávila, Jesús

In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice.

Rodríguez-Matellán, Alberto; Alcazar, Noelia; Hernández, Félix; Serrano, Manuel; Ávila, Jesús.

Afiliação

Rodríguez-Matellán A; Department of Molecular Neuropathology, Centro de Biología Molecular Severo Ochoa, CBMSO, CSIC-UAM, Madrid, Spain; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
Alcazar N; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.
Hernández F; Department of Molecular Neuropathology, Centro de Biología Molecular Severo Ochoa, CBMSO, CSIC-UAM, Madrid, Spain; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
Serrano M; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. Electronic address: manuel.serrano@irbbarcelona.org.
Ávila J; Department of Molecular Neuropathology, Centro de Biología Molecular Severo Ochoa, CBMSO, CSIC-UAM, Madrid, Spain; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Madrid, Spain. Electronic address: javila@cbm.csic.es.

Stem Cell Reports ; 15(5): 1056-1066, 2020 11 10.

Article em En | MEDLINE | ID: mdl-33096049

Assuntos

Envelhecimento/metabolismo; Reprogramação Celular; Giro Denteado/metabolismo; Neurogênese; Fatores de Transcrição/metabolismo; Envelhecimento/genética; Animais; Biomarcadores/metabolismo; Calbindina 2/metabolismo; Proteínas do Domínio Duplacortina; Epigenômica; Histonas/metabolismo; Memória; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Proteínas Associadas aos Microtúbulos/metabolismo; Plasticidade Neuronal; Neurônios/metabolismo; Neuropeptídeos/metabolismo; Receptores de N-Metil-D-Aspartato/metabolismo; Fatores de Transcrição/genética

Palavras-chave

Yamanaka factors; adult neurogenesis; aging; cellular reprogramming; doublecortin; epigenetics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Envelhecimento / Giro Denteado / Reprogramação Celular / Neurogênese Limite: Animals Idioma: En Revista: Stem Cell Reports Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha

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