Design and Synthesis of Various 5'-Deoxy-5'-(4-Substituted-1,2,3-Triazol-1-yl)-Uridine Analogues as Inhibitors of <i>Mycobacterium tuberculosis</i> Mur Ligases.

Hervin, Vincent; Arora, Ritu; Rani, Jyoti; Ramchandran, Srinivasan; Bajpai, Urmi; Agrofoglio, Luigi A; Roy, Vincent

Design and Synthesis of Various 5'-Deoxy-5'-(4-Substituted-1,2,3-Triazol-1-yl)-Uridine Analogues as Inhibitors of Mycobacterium tuberculosis Mur Ligases.

Hervin, Vincent; Arora, Ritu; Rani, Jyoti; Ramchandran, Srinivasan; Bajpai, Urmi; Agrofoglio, Luigi A; Roy, Vincent.

Afiliação

Hervin V; Institute of Organic and Analytical Chemistry, CNRS UMR 7311, Universite d'Orléans, Rue de Chartres, CEDEX 2, 45067 Orleans, France.
Arora R; Department of Biomedical Science, Acharya Narendra Dev College, University of Delhi, New Delhi 110019, India.
Rani J; Department of Biomedical Science, Acharya Narendra Dev College, University of Delhi, New Delhi 110019, India.
Ramchandran S; G N Ramachandran Knowledge of Centre, Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology (CSIR-IGIB), Room No. 130, Mathura Road, New Delhi 110025, India.
Bajpai U; G N Ramachandran Knowledge of Centre, Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology (CSIR-IGIB), Room No. 130, Mathura Road, New Delhi 110025, India.
Agrofoglio LA; Department of Biomedical Science, Acharya Narendra Dev College, University of Delhi, New Delhi 110019, India.
Roy V; Institute of Organic and Analytical Chemistry, CNRS UMR 7311, Universite d'Orléans, Rue de Chartres, CEDEX 2, 45067 Orleans, France.

Molecules ; 25(21)2020 Oct 26.

Article em En | MEDLINE | ID: mdl-33114668

Assuntos

Desenho de Fármacos; Mycobacterium tuberculosis/enzimologia; Peptídeo Sintases/antagonistas & inibidores; Triazóis/química; Uridina/síntese química; Uridina/farmacologia; Domínio Catalítico; Técnicas de Química Sintética; Inibidores Enzimáticos/síntese química; Inibidores Enzimáticos/química; Inibidores Enzimáticos/farmacologia; Simulação de Acoplamento Molecular; Peptídeo Sintases/química; Peptídeo Sintases/metabolismo; Uridina/química

Palavras-chave

Mur ligase; antibacterial agents; copper-catalyzed azide-alkyne cycloaddition; molecular modelling; nucleoside analogues

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeo Sintases / Triazóis / Uridina / Desenho de Fármacos / Mycobacterium tuberculosis Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França

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