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Transfer learning enables prediction of CYP2D6 haplotype function.
McInnes, Gregory; Dalton, Rachel; Sangkuhl, Katrin; Whirl-Carrillo, Michelle; Lee, Seung-Been; Tsao, Philip S; Gaedigk, Andrea; Altman, Russ B; Woodahl, Erica L.
Afiliação
  • McInnes G; Biomedical Informatics Training Program, Stanford University, Stanford, California, United States of America.
  • Dalton R; Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana, United States of America.
  • Sangkuhl K; Department of Biomedical and Translational Research, University of Florida, Gainesville, Florida, United States of America.
  • Whirl-Carrillo M; Department of Biomedical Data Science, Stanford University, Stanford, California, United States of America.
  • Lee SB; Department of Biomedical Data Science, Stanford University, Stanford, California, United States of America.
  • Tsao PS; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.
  • Gaedigk A; VA Palo Alto Epidemiology Research and Information Center for Genomics, VAPAHCS, Palo Alto, California, United States of America.
  • Altman RB; Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America.
  • Woodahl EL; Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Missouri, United States of America.
PLoS Comput Biol ; 16(11): e1008399, 2020 11.
Article em En | MEDLINE | ID: mdl-33137098
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocromo P-450 CYP2D6 / Aprendizado Profundo Tipo de estudo: Evaluation_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: PLoS Comput Biol Assunto da revista: BIOLOGIA / INFORMATICA MEDICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocromo P-450 CYP2D6 / Aprendizado Profundo Tipo de estudo: Evaluation_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: PLoS Comput Biol Assunto da revista: BIOLOGIA / INFORMATICA MEDICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos