Design, synthesis and antitumor evaluation of novel 5-methylpyrazolo[1,5-a]pyrimidine derivatives as potential c-Met inhibitors.

Luo, Guolin; Ma, Yanxia; Liang, Xintong; Xie, Guoquan; Luo, Yingqi; Zha, Dailong; Wang, Sheng; Yu, Lihong; Zheng, Xuehua; Wu, Wenhao; Zhang, Chao

Luo, Guolin; Ma, Yanxia; Liang, Xintong; Xie, Guoquan; Luo, Yingqi; Zha, Dailong; Wang, Sheng; Yu, Lihong; Zheng, Xuehua; Wu, Wenhao; Zhang, Chao.

Afiliação

Luo G; Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, Guangdong, PR China.
Ma Y; Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, Guangdong, PR China.
Liang X; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510700, Guangdong, PR China.
Xie G; Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, Guangdong, PR China.
Luo Y; Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, Guangdong, PR China.
Zha D; Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, Guangdong, PR China.
Wang S; Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, Guangdong, PR China.
Yu L; Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, Guangdong, PR China.
Zheng X; Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, Guangdong, PR China.
Wu W; Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, Guangdong, PR China. Electronic address: wenhao_wu@gzhmu.edu.cn.
Zhang C; Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, Guangdong, PR China. Electronic address: chao-zh@163.com.

Bioorg Chem ; 104: 104356, 2020 11.

Article em En | MEDLINE | ID: mdl-33142417

Assuntos

Antineoplásicos/farmacologia; Desenho de Fármacos; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas c-met/antagonistas & inibidores; Pirazóis/farmacologia; Pirimidinas/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Modelos Moleculares; Estrutura Molecular; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/química; Proteínas Proto-Oncogênicas c-met/metabolismo; Pirazóis/síntese química; Pirazóis/química; Pirimidinas/síntese química; Pirimidinas/química; Relação Estrutura-Atividade

Palavras-chave

Antitumor activity; Molecular docking; Pyrazolo[1,5-a]pyrimidine derivatives; Synthesis; c-Met kinase inhibitor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Desenho de Fármacos / Proteínas Proto-Oncogênicas c-met / Inibidores de Proteínas Quinases / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article

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