Case of vitiligo universalis as a sequela of drug-induced hypersensitivity syndrome.
J Dermatol
; 48(1): 92-95, 2021 Jan.
Article
em En
| MEDLINE
| ID: mdl-33180345
ABSTRACT
Drug-induced hypersensitivity syndrome (DIHS) is a type of severe drug adverse reaction with high morbidity and mortality. DIHS patients have been reported to subsequently develop autoimmune disease, which may be followed by end-organ decompensation. We report a 47-year-old woman who presented with fever, generalized maculopapular eruption, facial edema and eosinophilia with liver function impairment after taking celecoxib and sulfasalazine for 1 month. The patient was diagnosed with definite DIHS. The patient was treated with immunosuppressants including systemic corticosteroid for approximately 1.5 years due to recurrent episodes. Reactivation of human herpesvirus 6 and possible reactivation of cytomegalovirus were detected. Generalized hypopigmentation of the skin and leukotrichia were noted 4 months after the onset of DIHS. Histopathological examination confirmed the diagnosis of vitiligo. Some spontaneous repigmentation was noted 4 years after DIHS without specific treatment. Further immunoserology study showed elevated plasma C-X-C motif chemokine 10 level, which is related to vitiligo activity, in our patient. The occurrence of widespread vitiligo after DIHS is an extremely rare condition. This case provides an important reminder for physicians to monitor such severe complications after DIHS.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitiligo
/
Preparações Farmacêuticas
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Hipopigmentação
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Hipersensibilidade a Drogas
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Eosinofilia
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Síndrome de Hipersensibilidade a Medicamentos
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
J Dermatol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Taiwan