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Assessment of Interleukin-27 and Chemokine RANTES as Biomarkers for Early Onset Neonatal Sepsis.
Fahmy, Ehab M; Kamel, Nesreen M; Abdelsadik, Ahmed; Botrous, Osama E; Sheemy, Mostafa S; Soliman, Safwat R; Hodeib, Mahmoud M.
Afiliação
  • Fahmy EM; Department of Medical Microbiology & Immunology, Faculty of Medicine, Aswan University, Aswan, Egypt.
  • Kamel NM; Department of Chemical Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
  • Abdelsadik A; Department of Zoology, Faculty of Science, Aswan University, Aswan, Egypt.
  • Botrous OE; Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
  • Sheemy MS; Department of Medical Microbiology & Immunology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
  • Soliman SR; General Health Hospital, Beni-Suef University, Beni-Suef, Egypt.
  • Hodeib MM; Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Egypt J Immunol ; 27(1): 9-18, 2020 Jan.
Article em En | MEDLINE | ID: mdl-33180383
ABSTRACT
Early-onset neonatal sepsis (EONS) is a global health problem with high morbidity and mortality rates. Early diagnosis is a critical issue in determining treatment strategies. There is no single diagnostic test that can fulfill all requirements of the ideal biomarker yet. The current study enrolled 47 cases with EONS, admitted to the Neonatal Intensive Care Units at Beni-Suef University teaching Hospital from February 2017 to November 2017 and 37 apparently healthy controls. All were subjected to routine laboratory tests and serum concentration of IL-27 and regulation on activation normal T-cell expressed and secreted (RANTES) were measured. Significantly higher concentrations of IL-27 were observed in the septic group while RANTES were significantly lower in comparison to the controls. Moreover, there were no significant correlations between levels of IL-27 and RANTES either in the septic or the control group. Sensitivity, specificity, positive and negative predictive values for IL-27 were 93.6%, 81.1%, 86.3% and 90.9, respectively while for RANTES such values were 68.1%, 78.4%, 80% and 65.9%, respectively. A combination of both markers showed 97.3% specificity for sepsis. In conclusion, IL-27 is a useful and sensitive biomarker either individually or combined with other candidate biomarkers like RANTES.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucinas / Quimiocina CCL5 / Sepse Neonatal Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans País/Região como assunto: Africa Idioma: En Revista: Egypt J Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Egito
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucinas / Quimiocina CCL5 / Sepse Neonatal Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans País/Região como assunto: Africa Idioma: En Revista: Egypt J Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Egito