Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site.

Terzyan, Simon S; Nguyen, Luong T; Burgett, Anthony W G; Heroux, Annie; Smith, Clyde A; You, Youngjae; Hanigan, Marie H

Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site.

Terzyan, Simon S; Nguyen, Luong T; Burgett, Anthony W G; Heroux, Annie; Smith, Clyde A; You, Youngjae; Hanigan, Marie H.

Afiliação

Terzyan SS; Laboratory of Biomolecular Structure and Function, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Nguyen LT; Department of Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, New York, USA.
Burgett AWG; Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Heroux A; Energy Sciences Directorate/Photon Science Division, Brookhaven National Laboratory, Upton, New York, USA.
Smith CA; Stanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park, California, USA.
You Y; Department of Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, New York, USA.
Hanigan MH; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. Electronic address: marie-hanigan@ouhsc.edu.

J Biol Chem ; 296: 100066, 2021.

Article em En | MEDLINE | ID: mdl-33187988

Assuntos

Dipeptídeos/metabolismo; Inibidores Enzimáticos/metabolismo; gama-Glutamiltransferase/antagonistas & inibidores; Sítios de Ligação; Domínio Catalítico; Cristalografia por Raios X; Dipeptídeos/química; Humanos; Modelos Moleculares; Conformação Proteica; gama-Glutamiltransferase/química; gama-Glutamiltransferase/metabolismo

Palavras-chave

crystal structure; crystallography; enzyme; enzyme inhibitor; glutathione; structural biology; Î³-glutamyl transferase; Î³-glutamyl transpeptidase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dipeptídeos / Inibidores Enzimáticos / Gama-Glutamiltransferase Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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