Differential diagnosis and prospective grading of COVID-19 at the early stage with simple hematological and biochemical variables.
Diagn Microbiol Infect Dis
; 99(2): 115169, 2021 Feb.
Article
em En
| MEDLINE
| ID: mdl-33202303
ABSTRACT
We evaluated simple laboratory variables to discriminate COVID-19 from bacterial pneumonia or influenza and for the prospective grading of COVID-19. Multivariate logistic regression and receiver operating characteristic curve were used to estimate the diagnostic performance of the significant discriminating variables. A comparative analysis was performed with different severity. The leukocytosis (Pâ¯=â¯0.017) and eosinopenia (Pâ¯=â¯0.001) were discriminating variables between COVID-19 and bacterial pneumonia with area under the curve (AUC) of 0.778 and 0.825. Monocytosis (Pâ¯=â¯0.003), the decreased lymphocyte-to-monocyte ratio (Pâ¯<â¯0.001), and the increased neutrophil-to-lymphocyte ratio (NLR) (Pâ¯=â¯0.028) were predictive of influenza with AUC of 0.723, 0.895, and 0.783, respectively. Serum amyloid protein, lactate dehydrogenase, CD3+ cells, and the fibrinogen degradation products had a good correlation with the severity of COVID-19 graded by age (≥50) and NLR (≥3.13). Simple laboratory variables are helpful for rapid diagnosis on admission and hierarchical management of COVID-19 patients.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Índice de Gravidade de Doença
/
Pneumonia Bacteriana
/
Influenza Humana
/
COVID-19
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Diagn Microbiol Infect Dis
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China