Hemodynamic effects of the anti-hypertensive agent ketanserin in hypertension in man.
Acta Cardiol
; 42(5): 329-37, 1987.
Article
em En
| MEDLINE
| ID: mdl-3321806
ABSTRACT
The hemodynamic changes caused by ketanserin, an anti-hypertensive agent with S2-serotonergic receptor and alpha 1-adrenoceptor blocking properties, are reviewed in patients with essential hypertension. The hemodynamic profile associates a decrease in total peripheral resistance, an unchanged cardiac output, and a modest reflex cardiac stimulation. Whether the drug reverses the other hemodynamic abnormalities of essential hypertension, such as reduced arterial and venous compliances and increased cardiac mass, remains largely unknown. Evaluation of the changes in arterial and venous systems will be important in the view that the pharmacological profile of ketanserin could be involved in the modifications of the arterial wall observed in hypertension and atherosclerosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ketanserina
/
Hemodinâmica
/
Hipertensão
Limite:
Humans
Idioma:
En
Revista:
Acta Cardiol
Ano de publicação:
1987
Tipo de documento:
Article