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GLI3 Is Associated With Neuronal Differentiation in SHH-Activated and WNT-Activated Medulloblastoma.
Natsumeda, Manabu; Miyahara, Hiroaki; Yoshimura, Junichi; Nakata, Satoshi; Nozawa, Takanori; Ito, Junko; Kanemaru, Yu; Watanabe, Jun; Tsukamoto, Yoshihiro; Okada, Masayasu; Oishi, Makoto; Hirato, Junko; Wataya, Takafumi; Ahsan, Sama; Tateishi, Kensuke; Yamamoto, Tetsuya; Rodriguez, Fausto J; Takahashi, Hitoshi; Hovestadt, Volker; Suva, Mario L; Taylor, Michael D; Eberhart, Charles G; Fujii, Yukihiko; Kakita, Akiyoshi.
Afiliação
  • Natsumeda M; From the Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
  • Miyahara H; Department of Pediatrics, Oita University Faculty of Medicine, Yufu, Japan.
  • Yoshimura J; Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Japan.
  • Nakata S; From the Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
  • Nozawa T; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland.
  • Ito J; From the Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
  • Kanemaru Y; From the Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
  • Watanabe J; Department of Pathology, Brain Research Institute, Niigata University.
  • Tsukamoto Y; From the Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
  • Okada M; From the Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
  • Oishi M; From the Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
  • Hirato J; From the Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
  • Wataya T; From the Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
  • Ahsan S; Department of Pathology, Public Tomioka General Hospital, Tomioka, Japan.
  • Tateishi K; Department of Human Pathology, Gunma University, Maebashi, Japan.
  • Yamamoto T; Department of Human Pathology, Gunma University, Maebashi, Japan.
  • Rodriguez FJ; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland.
  • Takahashi H; Department of Neurosurgery, Yokohama City University, Yokohama, Japan.
  • Hovestadt V; Department of Neurosurgery, Yokohama City University, Yokohama, Japan.
  • Suva ML; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland.
  • Taylor MD; Department of Pathology, Brain Research Institute, Niigata University.
  • Eberhart CG; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusettes.
  • Fujii Y; Broad Institute of Harvard and MIT, Cambridge, Massachusettes.
  • Kakita A; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusettes.
J Neuropathol Exp Neurol ; 80(2): 129-136, 2021 01 20.
Article em En | MEDLINE | ID: mdl-33249504
ABSTRACT
Glioma-associated oncogene homolog 3 (GLI3), whose main function is to inhibit GLI1, has been associated with neuronal differentiation in medulloblastoma. However, it is not clear what molecular subtype(s) show increased GLI3 expression. GLI3 levels were assessed by immunohistochemistry in 2 independent cohorts, including a total of 88 cases, and found to be high in both WNT- and SHH-activated medulloblastoma. Analysis of bulk mRNA expression data and single cell RNA sequencing studies confirmed that GLI1 and GLI3 are highly expressed in SHH-activated medulloblastoma, whereas GLI3 but not GLI1 is highly expressed in WNT-activated medulloblastoma. Immunohistochemical analysis has shown that GLI3 is expressed inside the neuronal differentiated nodules of SHH-activated medulloblastoma, whereas GLI1/2 are expressed in desmoplastic areas. In contrast, GLI3 is diffusely expressed in WNT-activated medulloblastoma, whereas GLI1 is suppressed. Our data suggest that GLI3 may be a master regulator of neuronal differentiation and morphology in these subgroups.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Neoplasias Cerebelares / Proteínas Wnt / Proteínas Hedgehog / Proteína Gli3 com Dedos de Zinco / Meduloblastoma / Proteínas do Tecido Nervoso / Neurônios Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: J Neuropathol Exp Neurol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Neoplasias Cerebelares / Proteínas Wnt / Proteínas Hedgehog / Proteína Gli3 com Dedos de Zinco / Meduloblastoma / Proteínas do Tecido Nervoso / Neurônios Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: J Neuropathol Exp Neurol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão