The Effect of Exercise During Pregnancy on Maternal and Offspring Vascular Outcomes: a Pilot Study.
Reprod Sci
; 28(2): 510-523, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33258064
ABSTRACT
The aim of this pilot study is to obtain estimates for the change in maternal cerebrovascular (primary) and offspring vascular structure (secondary) during healthy pregnancy that includes structured exercise. Eighteen pregnant women self-assigned to a moderate-intensity aerobic exercise intervention or a control group. Maternal cerebral blood flow (CBF) at the middle cerebral artery, cerebro- and peripheral-vascular function was assessed at the end of each trimester. Offspring carotid artery intima-media thickness (IMT) was measured within 12 weeks of birth. For exploratory purposes, we performed statistical analysis to provide estimates of the change for primary and secondary outcome variables. Maternal CBF reduced (- 8 cm s-1 [- 14 to - 2]) with evidence of change to cerebral autoregulation (normalised gain 0.12 %cm s-1% mmHg-1mmHg/% [- 0.18 to 0.40]) during pregnancy. Offspring carotid IMT was smaller in the exercise group (- 0.04 mm [- 0.12-0.03]) compared with controls. Based upon this data, a sample size of 33 and 57 in each group is required for low-frequency normalised gain and offspring IMT, respectively. This would provide 90% power to detect statistically significant (P < 0.05) between group differences in a randomised controlled trial. CBF is reduced in pregnancy, possibly due to reduced vascular resistance and altered maternal cerebral autoregulation. Maternal exercise had negligible effects on cerebrovascular adaptation to pregnancy, but we observed lower offspring carotid artery wall thickness following maternal exercise. Our directional findings and sample size estimations should be explored in a fully powered randomised control trial.Clinical trial registration The trial was registered on March 14th at https//register.clinicaltrials.gov (NCT03079258). Participant enrolment began on 3rd April 2016.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artérias Carótidas
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Circulação Cerebrovascular
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Artéria Cerebral Média
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Terapia por Exercício
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Saúde Materna
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Female
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Humans
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Infant
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Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Revista:
Reprod Sci
Assunto da revista:
MEDICINA REPRODUTIVA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Reino Unido