DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the <i>RB1</i> gene promoter.

Raizis, A M; Racher, H M; Foucal, A; Dimaras, H; Gallie, B L; George, P M

DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the RB1 gene promoter.

Raizis, A M; Racher, H M; Foucal, A; Dimaras, H; Gallie, B L; George, P M.

Afiliação

Raizis AM; C/o Dept. of Molecular Pathology, Canterbury Health Laboratories, Christchurch, New Zealand.
Racher HM; Department of Genetics, c/o Impact Genetics, Bowmanville, Ontario, Canada.
Foucal A; Université de Nantes, INSERM, l'institut du thorax, F-44000 Nantes, France.
Dimaras H; Departments of Ophthalmology & Vision Sciences, The Hospital for Sick Children, Toronto, Canada.
Gallie BL; Department of Ophthalmology & Vision Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada.
George PM; Division of Clinical Public Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Epigenetics ; 16(9): 940-954, 2021 09.

Article em En | MEDLINE | ID: mdl-33258708

Assuntos

Neoplasias da Retina; Retinoblastoma; Pré-Escolar; Metilação de DNA; Epigênese Genética; Genes do Retinoblastoma; Humanos; Neoplasias da Retina/genética; Retinoblastoma/genética; Proteínas de Ligação a Retinoblastoma; Ubiquitina-Proteína Ligases

Palavras-chave

CTCF; DNA hypermethylation; Epimutations; RB1; cancer; loop extrusion; promoter; retinoblastoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retinoblastoma / Neoplasias da Retina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Child, preschool / Humans Idioma: En Revista: Epigenetics Assunto da revista: GENETICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Nova Zelândia

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