Periprosthetic osteolysis: a narrative review.
J Biol Regul Homeost Agents
; 34(4 Suppl. 3): 405-417. Congress of the Italian Orthopaedic Research Society, 2020.
Article
em En
| MEDLINE
| ID: mdl-33261304
ABSTRACT
Periprosthetic osteolysis is still one of the major limitations of prosthetic joints longevity. The process of this "silent" iatrogenic disease involves both mechanical and biological factors that initiate a local immune response in the periprosthetic tissue that eventually lead to implant loosening and failure. There are many causes of the primary aseptic loosening inside the periprosthetic microenvironment, but the most important elements are the wear debris and the cell-particle interactions. Together with implant position, micromotion, bearings, joint fluid pressure, and increased load on the joints drive the pathogenesis of the disease. This narrative review aims to summarise recent studies describing the biological and mechanical factors in the pathogenesis of osteolysis and some of the current pharmacological attempts to "rescue" a failing implant.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteólise
/
Prótese Articular
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
J Biol Regul Homeost Agents
Assunto da revista:
BIOLOGIA
/
BIOQUIMICA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Itália