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Reduced plasmablast frequency is associated with seronegative myasthenia gravis.
Guptill, Jeffrey T; Barfield, Richard; Chan, Cliburn; Russo, Melissa A; Emmett, Doug; Raja, Shruti; Massey, Janice M; Juel, Vern C; Hobson-Webb, Lisa D; Gable, Karissa L; Gonzalez, Natalia; Hammett, Alex; Howard, James F; Chopra, Manisha; Kaminski, Henry J; Siddiqi, Zaeem A; Migdal, Mattingly; Yi, John S.
Afiliação
  • Guptill JT; Neuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
  • Barfield R; Duke Clinical Research Institute, Durham, North Carolina, USA.
  • Chan C; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.
  • Russo MA; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.
  • Emmett D; Neuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
  • Raja S; Neuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
  • Massey JM; Neuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
  • Juel VC; Neuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
  • Hobson-Webb LD; Neuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
  • Gable KL; Neuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
  • Gonzalez N; Neuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
  • Hammett A; Neuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
  • Howard JF; Duke Clinical Research Institute, Durham, North Carolina, USA.
  • Chopra M; Neuromuscular Disorders Section, Department of Neurology, The University of North Carolina, Chapel Hill, North Carolina, USA.
  • Kaminski HJ; Neuromuscular Disorders Section, Department of Neurology, The University of North Carolina, Chapel Hill, North Carolina, USA.
  • Siddiqi ZA; Department of Neurology, George Washington University, Washington, District of Columbia, USA.
  • Migdal M; Division of Neurology, University of Alberta, Edmonton, Alberta, Canada.
  • Yi JS; The University of North Carolina, Chapel Hill, North Carolina, USA.
Muscle Nerve ; 63(4): 577-585, 2021 04.
Article em En | MEDLINE | ID: mdl-33294984
BACKGROUND: The immunopathology of autoimmune seronegative myasthenia gravis (SN MG) is poorly understood. Our objective was to determine immune profiles associated with a diagnosis of SN MG. METHODS: We performed high-dimensional flow cytometry on blood samples from SN MG patients (N = 68), healthy controls (N = 46), and acetylcholine receptor antibody (AChR+) MG patients (N = 27). We compared 12 immune cell subsets in SN MG to controls using logistic modeling via a discovery-replication design. An exploratory analysis fit a multinomial model comparing AChR+ MG and controls to SN MG. RESULTS: An increase in CD19+ CD20- CD38hi plasmablast frequencies was associated with lower odds of being a SN MG case in both the discovery and replication analyses (discovery P-value = .0003, replication P-value = .0021). Interleukin (IL) -21 producing helper T cell frequencies were associated with a diagnosis of AChR+ MG (P = .004). CONCLUSIONS: Reduced plasmablast frequencies are strongly associated with a SN MG diagnosis and may be a useful diagnostic biomarker in the future.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmócitos / Autoanticorpos / Receptores Colinérgicos / Miastenia Gravis Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Muscle Nerve Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmócitos / Autoanticorpos / Receptores Colinérgicos / Miastenia Gravis Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Muscle Nerve Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos