The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high-fat diet.

McEwan, Andrew; Erickson, Johanna Celene; Davidson, Connor; Heijkoop, Jenny; Turnbull, Yvonne; Delibegovic, Mirela; Murgatroyd, Christopher; MacKenzie, Alasdair

McEwan, Andrew; Erickson, Johanna Celene; Davidson, Connor; Heijkoop, Jenny; Turnbull, Yvonne; Delibegovic, Mirela; Murgatroyd, Christopher; MacKenzie, Alasdair.

Afiliação

McEwan A; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK.
Erickson JC; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK.
Davidson C; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK.
Heijkoop J; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK.
Turnbull Y; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK.
Delibegovic M; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK.
Murgatroyd C; Manchester Metropolitan University, Manchester, UK.
MacKenzie A; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK. mbi167@abdn.ac.uk.

Cell Mol Life Sci ; 78(6): 3045-3055, 2021 Mar.

Article em En | MEDLINE | ID: mdl-33313982

Assuntos

Alcoolismo/patologia; Ansiedade/patologia; Dieta Hiperlipídica; Elementos Facilitadores Genéticos/genética; 5-Metilcitosina/metabolismo; Alcoolismo/genética; Tonsila do Cerebelo/metabolismo; Animais; Ansiedade/genética; Linhagem Celular Tumoral; Metilação de DNA; Modelos Animais de Doenças; Proteína 1 de Resposta de Crescimento Precoce/metabolismo; Epigênese Genética; Feminino; Humanos; Hipotálamo/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Proteína Quinase C/química; Proteína Quinase C/metabolismo

Palavras-chave

5mC/5hmC content; Anxiety and substance abuse; CRISPR genome editing; EGR1; Early life stress; Fat preference; GAL5.1 enhancer sequence; Galanin; Gene regulation; Protein Kinase C

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiedade / Elementos Facilitadores Genéticos / Alcoolismo / Dieta Hiperlipídica Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido

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