<i>In vivo</i> biodistribution study of TAT-L-Sco2 fusion protein, developed as protein therapeutic for mitochondrial disorders attributed to <i>SCO2</i> mutations.

Kaiafas, Georgios C; Papagiannopoulou, Dionysia; Miliotou, &#913;ndroulla N; Tsingotjidou, Anastasia S; Chalkidou, Parthenopi C; Tsika, Aikaterini C; Spyroulias, George A; Tsiftsoglou, Asterios S; Papadopoulou, Lefkothea C

In vivo biodistribution study of TAT-L-Sco2 fusion protein, developed as protein therapeutic for mitochondrial disorders attributed to SCO2 mutations.

Kaiafas, Georgios C; Papagiannopoulou, Dionysia; Miliotou, Αndroulla N; Tsingotjidou, Anastasia S; Chalkidou, Parthenopi C; Tsika, Aikaterini C; Spyroulias, George A; Tsiftsoglou, Asterios S; Papadopoulou, Lefkothea C.

Afiliação

Kaiafas GC; Laboratory of Pharmacology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki 54124, Macedonia, Greece.
Papagiannopoulou D; Laboratory of Medicinal Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki 54124, Macedonia, Greece.
Miliotou ΑN; Laboratory of Pharmacology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki 54124, Macedonia, Greece.
Tsingotjidou AS; Laboratory of Anatomy, Histology and Embryology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece.
Chalkidou PC; Laboratory of Pharmacology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki 54124, Macedonia, Greece.
Tsika AC; Department of Pharmacy, University of Patras, 26504 Patras, Greece.
Spyroulias GA; Department of Pharmacy, University of Patras, 26504 Patras, Greece.
Tsiftsoglou AS; Laboratory of Pharmacology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki 54124, Macedonia, Greece.
Papadopoulou LC; Laboratory of Pharmacology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki 54124, Macedonia, Greece.

Mol Genet Metab Rep ; 25: 100683, 2020 Dec.

Article em En | MEDLINE | ID: mdl-33318931

Palavras-chave

99mTc, Technetium-99 m.; BSA, Bovine Serum Albumin;; COX, Cytochrome c oxidase;; FBS, Fetal bovine serum;; IBs, Inclusion bodies;; ID, Injected dose;; PBS, Phosphate buffered saline;; PRT, Protein Replacement Therapy;; PTD, Protein Transduction Domain;; RA, Radioactivity;; RT, Room Temperature;; SD, Standard Deviation;; SEC, Size Exclusion Chromatography;; TAT-L-Sco2, 10xHis-XaSITE-TAT-L-Sco2-HA;; i.p., Intraperitoneal;; i.v., Intravenous;; l-Arg, l-Arginine;; p.i., Post-injection;

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mol Genet Metab Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Grécia

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