A Blueprint for Identifying Phenotypes and Drug Targets in Complex Disorders with Empirical Dynamics.
Patterns (N Y)
; 1(9): 100138, 2020 Dec 11.
Article
em En
| MEDLINE
| ID: mdl-33336196
ABSTRACT
A central challenge in medicine is translating from observational understanding to mechanistic understanding, where some observations are recognized as causes for the others. This can lead not only to new treatments and understanding, but also to recognition of novel phenotypes. Here, we apply a collection of mathematical techniques (empirical dynamics), which infer mechanistic networks in a model-free manner from longitudinal data, to hematopoiesis. Our study consists of three subjects with markers for cyclic thrombocytopenia, in which multiple cells and proteins undergo abnormal oscillations. One subject has atypical markers and may represent a rare phenotype. Our analyses support this contention, and also lend new evidence to a theory for the cause of this disorder. Simulations of an intervention yield encouraging results, even when applied to patient data outside our three subjects. These successes suggest that this blueprint has broader applicability in understanding and treating complex disorders.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Patterns (N Y)
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos