A paradox: Fe2+-containing agents decreased ROS and apoptosis induced by CoNPs in vascular endothelial cells by inhibiting HIF-1&#945;.

Zhu, Wenfeng; Liu, Yake; Wang, Wei; Zhou, Zihua; Gu, Jin-Hua; Zhang, Zexu; Sun, Huanjian; Liu, Fan

A paradox: Fe2+-containing agents decreased ROS and apoptosis induced by CoNPs in vascular endothelial cells by inhibiting HIF-1α.

Zhu, Wenfeng; Liu, Yake; Wang, Wei; Zhou, Zihua; Gu, Jin-Hua; Zhang, Zexu; Sun, Huanjian; Liu, Fan.

Afiliação

Zhu W; Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Liu Y; Department of Orthopaedics, The Sixth Affiliated Hospital of Nantong University, Yancheng, Jiangsu Province, China.
Wang W; Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Zhou Z; Orthopaedic Laboratory, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Gu JH; Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Zhang Z; Orthopaedic Laboratory, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Sun H; Department of Clinical Pharmacy, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, Jiangsu Province, China.
Liu F; Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.

Biosci Rep ; 41(1)2021 01 29.

Article em En | MEDLINE | ID: mdl-33345265

Assuntos

Apoptose/efeitos dos fármacos; Cobalto/química; Endotélio Vascular/efeitos dos fármacos; Compostos Ferrosos/farmacologia; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Nanopartículas Metálicas/toxicidade; Espécies Reativas de Oxigênio/metabolismo; Endotélio Vascular/citologia; Endotélio Vascular/metabolismo; Compostos Ferrosos/química; Compostos Ferrosos/metabolismo; Células Endoteliais da Veia Umbilical Humana; Humanos; Nanopartículas Metálicas/química; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

CoNPs; Fe2+-containing agents; hypoxia-inducible factor; vascular endothelial cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endotélio Vascular / Compostos Ferrosos / Espécies Reativas de Oxigênio / Cobalto / Apoptose / Subunidade alfa do Fator 1 Induzível por Hipóxia / Nanopartículas Metálicas Limite: Humans Idioma: En Revista: Biosci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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